New paper showing that distinct macrophages can cross-prime antiviral CTL faster than DCs

KEY POINTS

  • RPM and BM-DCs, not cDC1, cross-prime CTL via the MR-dependent cytosolic pathway.

  • RPM and cDC1 cross-prime at different phases after infection/immunization.

  • RPM produce distinct early effector CTL that limit early viral spread.

 

https://www.ncbi.nlm.nih.gov/pubmed/31776205